The Portal Interprets Cancer Genomic Variants

The MTB portal is a clinical decision support system and data sharing infrastructure used across several comprehensivecancer centers connected by the Cancer Core Europe. Here, we provide an open lightweight version of its analytical framework that performs a general interpretation of the functional and predictive relevance of the gene variants uploaded by the user (see the FAQ page for more details).

The analyses provided by the public version of the MTB portal are limited to a general classification of the functional and predictive relevance of the variants uploaded by the user based on the combination of multiple knowledge sources, bioinformatics tools and data bases. Note that this public resource does not include variant interpretation nuances or ad-hoc clinical flags that are relevant for the clinical decision making, and thus this resource is intended for research purposes only (see the FAQ page for more details).

Results of the MTBP analyses are structured in HTML reports where variants are classified according to their functional relevance, and those described as cancer biomarkers are ranked according to their level of actionability. These documents provide detailed variant annotation, evidence supporting each given assertion and access to original data sources through interactive elements. This is aimed to empower in-depth review of available information.